![]() Previously, we reported that hydrophobic HPAAs formed large aggregates in COS-7 cells. The results indicate that hydrophobic HPAAs interact with themselves and with other hydrophobic HPAAs. In this study, potential HPAA-HPAA interactions were examined by yeast two-hybrid assays using HPAAs of approximately 30 residues in length. To this day, nine polyglutamine-related diseases and nine polyalanine-related diseases have been reported, including Huntington's disease and oculopharyngeal muscular dystrophy. Some inherited diseases are caused by proteins in which HPAAs are expanded to an excessive length. ![]() ![]() Many human proteins contain consecutive amino acid repeats, known as homopolymeric amino acid (HPAA) tracts.
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